PHOTOSENSITIZING EFFECTS OF BILIRUBIN ON ANIMAL CELLS IN CULTURE
Abstract
The studies performed in this work have shown that the radiation exposure to LED sources with an emission band maximum of about 465 nm corresponding to the absorption spectrum of bilirubin is able to cause damaging effects on animal cells in culture, being in a logarithmic growth stage, that have been pre-incubated with bilirubin. The photobiological effect is caused by photo dynamic processes with participation of singlet oxygen generated by a triplet-excited sensitizer. The type of cell survival depending on an energy dose indicates that the sensitizer serves as bilirubin but not its photoproducts.
About the Authors
O. A. Kozlenkova
B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
I. G. Plavskaya
B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
A. V. Mikulich
B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
I. A. Leusenko
B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
A. I. Tretyakova
B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
V. Yu. Plavskii
B. I. Stepanov Institute of Physics of the National Academy of Sciences of Belarus, Minsk
Belarus
Belarus
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